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Menopause Brain Fog: Why it Happens During Midlife

Menopause brain fog isn’t in your head. Learn how hormones, sleep, stress, and blood sugar may play a role in midlife mental clarity.

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Menopause Brain Fog: Why it Happens During Midlife

By Kristen Carli, MS, RD

Do you ever walk into a room and forget why you entered? Do you ever forget a familiar word mid-sentence? Do you ever feel like no matter how hard you try to concentrate, you just can’t seem to focus? If you are a female in your 40s or 50s, you are not alone. This concept, called menopause brain fog, is a common symptom of this crucial hormonal time period. Turns out, the hormonal shifts that occur during this phase, not only affect your menstrual cycles, but can have additional effects on your cognitive functionality. But don’t worry, there are a few things you can do that may help to alleviate this symptom.

What is Menopause Brain Fog?

So what exactly is menopause brain fog? It’s defined as the general lack of cognition that occurs during the period of perimenopause. It’s during this time that the female body stops going through the regular average 28-day menstrual cycle. Perimenopause could last a few months to upwards of ten years, but the average length is about four years1. This span officially ends with menopause, which is defined as the day when it’s been twelve months since you’ve had a period.

The brain fog that is associated with this time period includes forgetfulness, lack of concentration, diminished memory, reduced thinking skills, decreased verbal learning, minimized processing speed, deficiency of attention, etc2. About two thirds of women report experiencing these symptoms during perimenopause3.

Why It Happens: The Hormonal Connection

The female hormones involved with reproduction, estrogen and progesterone, do far more than simply regulate the menstrual cycle. These hormones are actively involved in the brain, due to their role in vascular health. Both estrogen and progesterone act as vasodilators, meaning that they relax vascular cells, widening blood vessels, which increases blood flow4. For veins in the brain, this is a critical way to increase blood flow to brain tissue, subsequently increasing cognitive performance.

During perimenopause, your body is experiencing rising and falling levels of both estrogen and progesterone. These swings in hormone levels produce all of the symptoms most commonly associated with menopause including hot flashes, sleep disturbances, dry skin, thinning hair, and, you guessed it, brain fog5.

Other Contributing Factors

While a decline in cognitive performance during perimenopause is likely a result of the hormone oscillations, it’s important to note other contributing factors that can pile on. For one, perimenopause occurs when women are in their 40s and 50s. A general result of aging is commonly a decline in cognitive function, so whether your brain fog is due to aging or menopause could be difficult to pinpoint.

Additionally, night sweats, common during perimenopause, could lead to a lack of good quality sleep. Without which, you may experience lack of mental clarity. This makes sense as you probably won’t feel focused after a night where you are tossing and turning, instead of getting quality shut-eye.

Stress and emotional well-being can also play a role. When you are under a considerable amount of stress, your working memory and attention are strained. The stage of midlife often results in a high level of stress as many individuals are still caring for their own children, but now are also caring for their aging parents. In addition to this, one might experience career pressure as well as typical daily stressors.

Taken together, these symptoms often compound on each other, overlapping and reinforcing each other, making brain fog feel even more pronounced.

It’s important to ensure the symptoms of brain fog are not resulting from nutrient deficiencies. Some nutrients like vitamin B12, vitamin D, and omega-3 fatty acids have a big role in concentration. Your doctor will be able to run a simple test to determine if you are deficient in any of these nutrients. If so, you’d likely be able to correct this through diet and supplementation.

Lastly, it’s possible that the fogginess you are experiencing is a result of blood sugar spikes and dips. When we eat, our blood sugar naturally rises. Our body works to move that sugar into our cells to power them. However, if we eat meals with too much sugar and not enough protein and fiber, we may experience a rapid rise in blood sugar and subsequent crash. These blood sugar swings could be the source of your brain fog.

Lifestyle Habits that May Support Mental Clarity

The Mediterranean diet is one of the most highly recommended diets by health care providers.

This diet, which is rich in fruits, vegetables, whole grains, legumes, nuts, seeds, prioritizes olive oil over butter and includes lean proteins like seafood, poultry, and limited red meats. The Mediterranean diet is widely researched and many studies indicate its role in improving numerous health outcomes including heart health6, brain health7, weight loss8, and even eye health9.

In regards to brain health, some experts think the Mediterranean diet is particularly beneficial due to the high content of omega-3 fatty acids10. While frequently produced in supplement form, these fats are also commonly found in fatty fish like salmon, green vegetables, and olive oil, which are all core components of the Mediterranean diet.

In addition to nutrition, physical activity also plays a role in cognitive health. This is because of its ability to increase blood flow, around the body, but especially in the brain. Research shows that exercise is associated with reduction in cognitive decline as well as other brain health benefits including increased sleep and improved mood11.

Lastly, as we age, research shows that mental stimulation and “brain exercise” is important to reduce cognitive decline. It’s recommended to regularly partake in simple brain-boosting activities like puzzles, crosswords, Sudoku, etc. By challenging the brain, you can help to keep your mind sharp12.

When to Talk to a Doctor

While the brain fog associated with perimenopause is temporary, fading by the time menopause is reached, it’s still something to be addressed by a healthcare provider. A doctor will make sure the brain fog you are experiencing is not due to other causes, like thyroid issues, vitamin deficiencies, sleep disorders, or more severe cognitive decline. If you are noticing you are forgetting common words, blanking on how to use common objects, unable to follow directions, and getting lost in familiar places, it’s important to tell your doctor immediately. Severe struggles such as these or others that impact your daily life need to be addressed by a professional.

Disclaimer: This blog contains promotional content about our products. The information provided is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. This content is not a substitute for medical advice. Always consult your healthcare provider before making changes to your wellness routine, especially if you are pregnant, nursing, taking medication, or have a medical condition.

References:

1. What is perimenopause? Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/21608-perimenopause.
2. Metcalf CA, Duffy KA, Page CE, Novick AM. Cognitive Problems in Perimenopause: A Review of Recent Evidence. Curr Psychiatry Rep. 2023;25(10):501-511. doi:10.1007/s11920-023-01447-3
3. Greendale GA, Karlamangla AS, Maki PM. The Menopause Transition and Cognition. JAMA.2020;323(15):1495–1496. doi:10.1001/jama.2020.1757
4. Raj A, Chakole S, Agrawal S, et al. The Impact of Menopause on Cardiovascular Aging: A Comprehensive Review of Androgen Influences. Cureus. 2023;15(8):e43569. Published 2023 Aug 16. doi:10.7759/cureus.43569
5. What is menopause? National Institute on Aging. https://www.nia.nih.gov/health/menopause/what-menopause.
6. Pant A, Gribbin S, McIntyre D, et alPrimary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysisHeart 2023;109:1208-1215.
7. Shannon, O.M., Ranson, J.M., Gregory, S. et al. Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study. BMC Med 21, 81 (2023). https://doi.org/10.1186/s12916-023-02772-3
8. Poulimeneas D, Anastasiou CA, Santos I, Hill JO, Panagiotakos DB, Yannakoulia M. Exploring the relationship between the Mediterranean diet and weight loss maintenance: the MedWeight study. Br J Nutr. 2020;124(8):874-880. doi:10.1017/S0007114520001798
9. Pameijer, E.M., Heus, P., Damen, J.A.A., Spijker, R., Hooft, L., Ringens, P.J., Imhof, S.M. and van Leeuwen, R. (2022), What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review. Acta Ophthalmol, 100: e1541-e1552. https://doi.org/10.1111/aos.15191
10. Dighriri IM, Alsubaie AM, Hakami FM, et al. Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions: A Systematic Review. Cureus. 2022;14(10):e30091. Published 2022 Oct 9. doi:10.7759/cureus.30091
11. Falck RS, Davis JC, Best JR, Crockett RA, Liu-Ambrose T. Impact of exercise training on physical and cognitive function among older adults: A systematic review and meta-analysis. Neurobiology of Aging. 2019;79:119-130. doi:10.1016/j.neurobiolaging.2019.03.007
12. Cognitive Health and older adults | National Institute on Aging.https://www.nia.nih.gov/health/brain-health/cognitive-health-and-older-adults.

By Kristen Carli, MS, RD

Kristen Carli is the owner of Camelback Nutrition & Wellness, a private nutrition practice and consulting firm. She graduated from University of Arizona with a BA in psychology and then received a BS in dietetics from Arizona State University. After completion of the dietetic internship, she continued her education by receiving a MS in Human Nutrition from University of Western States. Having a passion for nutrition communication, she writes for many food and nutrition outlets as well as regularly develops recipes for food brands and media companies. Her nutrition expertise has been featured in InStyle, Bustle, Livestrong, The List, MyFitnessPal and many others. Additionally, Kristen is often featured via local TV segments sharing nutrition tips and tricks. She was selected to act as a Produce for Better Health Foundation Fruit and Vegetable Ambassador in Action, helping to promote the health benefits and importance of consuming fruits and vegetables, as well as a FoodMinds upwaRD winner for 2022, honoring up and coming media dietitians. You can find her reading, running, and exploring new restaurants with her husband and baby boy.

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